Type 2 Diabetes (T2D) is a chronic metabolic disease, which is caused by the failure of beta-cells in the pancreas and insulin resistance in peripheral tissue and characterized by high glucose levels in the blood. World-wide 382 Million people suffer from Diabetes which makes up 8,3% of the population. Due to this high proportion it is of high interest to find a cure for this disease.
The restoration of β-cell mass and function has therefore become a field of intensive research seeking for the next generation of anti-diabetic drugs. Tremendous efforts have been made on deciphering epigenetic regulations that control metabolic tissue function. For several years, the team led by Dr. Jean-Sebastien Annicotte has dissected the molecular links between insulin producing cells, insulin target tissues and T2D/obesity development. Especially, the team research has been focused on the role of cell cycle regulators and their transcriptional co-regulators in the control of metabolic homeostasis, T2D and obesity.
Nabil Rabhi, Pierre-Damien Denechaud, … Jean-Sébastien Annicotte (2016) KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response (Cell Reports) DOI: 10.1016/j.celrep.2016.03.079
Albert Giralt, Pierre-Damien Denechaud, … Lluis Fajas (2018) E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes (Molecular Metabolism) DOI: 10.1016/j.molmet.2018.02.011